Abstract
Objectives
Postmastectomy lymphoedema remains a disabling complication caused by treatment for breast cancer. The increased thickness of the dermal layer and the increased volume of the subcutis represent the most important contributions to the total swelling of the arm. Ultrasound imaging of the subcutaneous layer results in different patterns of reflected ultrasound waves depending on the morphological alternations that occurred due to impaired lymphatic drainage. The aim of this study was to compare these echographic images with those obtained using magnetic resonance imaging to explain the nature of the morphological changes.
Design
Observational study.
Setting
Patients were recruited from the Breast Clinic at the University Hospital Brussels.
Participants
Seven women (mean age 60 years) with unilateral breast cancer who subsequently developed lymphoedema.
Main outcome measures
The water displacement technique was applied to determine arm volumes, and echographic and magnetic resonance images were used to evaluate changes in tissue structures.
Results
Volumetric measurements of the arm (mean affected arm 3241
ml vs unaffected arm 2538ml) showed a significant increase in total arm volume of 703ml (95% confidence interval 324 to 1084ml). Using echography, the thickness of the dermal and subcutaneous layers showed an average increase of 0.2 to 0.8mm and 3.9 to 7.2mm, respectively. The differences between the affected arm and the unaffected arm for all upper and lower arm measurements (i.e. volumetry, dermal and subcutaneous thickness) were significant, but no significant differences were registered for hand measurements. On echography, the dermis showed uniform changes, with a homogenous hypo-echogenic appearance compared with the contralateral side due to water influx. Different patterns of structural changes could be visualised within the subcutis: (1) uniformly hypo-echogenic due to the diffuse spread of water through the subcutis; (2) hyperechogenic areas surrounded by hypo-echogenic streaks visualised on magnetic resonance imaging as adipose tissue surrounded by fluid embedded in fibrous tissue; and (3) homogenously hyperechogenic due to the overgrowth of adipose tissue with a minimal amount of water.
Conclusions
Echographic images can help to determine the likelihood that complex physical therapy will reduce lymphoedema, and evaluate treatment results by measuring tissue thickness and evaluating tissue consistency.
Citation
Postmastectomy lymphoedema: different patterns of fluid distribution visualised by ultrasound imaging compared with magnetic resonance imaging
An Tassenoy, Johan De Mey, Filip De Ridder, Peter Van Schuerbeeck, Tim Vanderhasselt, Jan Lamote, Pierre Lievens
Physiotherapy 1 September 2011 (volume 97 issue 3 Pages 234-243 DOI: 10.1016/j.physio.2010.08.003)